Researchers develop blood test for anxiety

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Researchers from Indiana University School of Medicine have successfully developed a blood test for anxiety. The test examines biomarkers that can help them objectively determine someone’s risk for developing anxiety, the severity of their current anxiety, and which therapies would likely treat their anxiety the best.

Now that the test has been validated by researchers, it is currently being developed for wider use by physicians by MindX Sciences.

“Many people are suffering from anxiety, which can be very disabling and interfere with daily life,” said professor of psychiatry Alexander Niculescu, MD, Ph.D. “The current approach is to talk to people about how they feel to see if they could be on medications, but some medications can be addictive and create more problems. We wanted to see if our approach to identifying blood biomarkers could help us match people to existing medications that will work better and could be a non-addictive choice.”

Niculescu’s past research has led to the development of blood tests for pain, depression/bipolar disorder and post-traumatic stress disorder. This latest work, published in Molecular Psychiatry, uses similar methods for anxiety. The study included three independent cohorts — discovery, validation, and testing. Participants would complete a blood test every 3-6 months or whenever a new psychiatric hospitalization occurred. By examining the RNA biomarkers in the blood, researchers could identify a patient’s current state of anxiety and matches them with medications and nutraceuticals, showing how effective different options could be for them based on their biology.

“In addition to medications, there are other methods to treat anxiety, such as cognitive behavioral therapy or lifestyle changes,” Niculescu said. “But having something objective like this where we can know what someone’s current state is as well as their future risk and what treatment options match their profile is very powerful in helping people.”

A person’s biomarkers can also change over time. Niculescu said the test can help evaluate a person’s risk of developing higher levels of anxiety in the future as well as how other factors might impact their anxiety, like hormonal changes.

“There are people who have anxiety and it is not properly diagnosed, then they have panic attacks, but think they’re having a heart attack and up in the ER with all sorts of physical symptoms,” Niculescu said. “If we can know that earlier, then we can hopefully avoid this pain and suffering and treat them earlier with something that matches their profile.”

Niculescu said this new test could also be used in combination with the other blood tests his research has led to, providing a more comprehensive view of a patient’s mental health and risk of future mental health concerns. Researchers can also use the test to develop new treatments for anxiety that are more targeted to individual biomarkers.

“This is something that could be a panel test as part of a patient’s regular wellness visits to evaluate their mental health over time and prevent any future distress,” Niculescu said. “Prevention is better in the long run, so our goal is to be able to provide a comprehensive report for patients and their physicians using simply one tube of blood.”

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Understanding Olfactory Reference Syndrome ; It’s Treatment

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Understanding Olfactory Reference Syndrome

Understanding-Olfactory-Reference-Syndrome--Its-Treatment

Do you have friends who constantly use deodorants or frequently enquire about their body odor? If yes there is a chance of them struggling with olfactory reference syndrome. It is one of the most under-recognized psychiatric conditions.

Olfactory reference syndrome is also confused with a lot of other psychiatric conditions like obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD),  bromidrophobia, and a Japanese condition called Jiko-shu-kyofu.

However, many people have intrusive thoughts about having a bad body odor but that doesn’t necessarily mean you have Olfactory reference syndrome. When you develop irrational and obsessive thoughts about body odor and they start interfering with your daily life is a call for psychiatric attention.

Let’s explore all characteristics of Olfactory reference syndrome and how to treat olfactory reference syndrome…

What Is Olfactory Reference Syndrome?

Olfactory-Reference-Syndrome

Olfactory reference syndrome is also known as olfactory reference disorder. It can be characterized by an irrational obsession with being a foul-smelling person. They are constantly worried about various body odors coming from their armpits, sweat glands, or anal or vaginal odor.

Olfactory reference syndrome is a condition that feels very similar to having a phobia. An individual with olfactory reference syndrome is so scared of smelling bad that they can go to any lengths not to smell bad.

The preoccupation and obsession over their body odor are so irrational yet intense that they get anxious around people. They might quit going to games or refuse to dance even when their crush calls them.

Olfactory reference syndrome can stop you from achieving your goals. It can also reflect badly on your relationships. After all, you always escape because you fear you’ll smell bad. It can also lead to the development of severe mental health conditions like depression, social anxiety, loneliness, etc.

Also read: OCD And Social Anxiety: Is There A Relationship Between The Two?

Symptoms Of Olfactory Reference Syndrome

Reference-Syndrome

The signs and symptoms of olfactory reference syndrome are very obvious and easily identifiable. However, sometimes it can be confused with just being conscious about your body odor. Olfactory reference syndrome will affect your routine life and interfere with your decision-making.

If your consciousness about smelling good always is not coming in the way of your goals, there is probably nothing to worry about. Let’s have a look at some of the symptoms of olfactory reference syndrome that we need to watch out for;

  • Frequent showering, using perfumes/deodorants
  • Repeated use of grooming products
  • Constantly checking their body odor
  • Always enquire about their smell
  • Social avoidance because of fear of smelling bad
  • Escaping from work/school is an anxious response to a fear of having a foul odor
  • Suicidal ideations caused by extreme anxiety
  • Low self-esteem
  • Anxiety and depressive symptoms

What Treatments Work for Olfactory Reference Syndrome (ORS)?

Experts are still studying olfactory reference syndrome and its consequences. The treatment strategies for ORS are still a little hazy, there is enough proof that treatments for similar mental health conditions can work for olfactory reference syndrome as well.

The symptoms of olfactory reference syndrome are similar to that of obsessive-compulsive disorder; therefore, the treatment focuses on reframing the obsessive thoughts. Let’s have a look at all the treatment options that can work for olfactory reference syndrome;

  • Cognitive behavioral therapy (CBT): focuses on your thoughts and how you frame them. CBT helps you identify your obsessive thoughts, what triggers them, and how you can replace them with adaptive thoughts.
  • Clinical drugs: olfactory reference syndrome can give rise to extreme anxiety and emotional fluctuation. Such symptoms can be managed with help of some psychiatric drugs like serotonin reuptake inhibitors (SRIs) and selective serotonin reuptake inhibitors (SSRIs).

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The best treatment option for olfactory reference syndrome is considered a combination of medicines and psychotherapy. This is because the symptoms of ORS  include suicidal ideations, anxiety, and depressive thoughts.

Psychiatric drugs help in managing and reducing the intensity of olfactory reference syndrome symptoms. And the psychotherapy sessions will help in reframing your obsessive thoughts and help you fight your triggers.

 

 

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Am I depressed and what can help me?

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Psychotherapist John-Paul Davies explains what depression is, how it can feel, the self-help steps that help and why working with a therapist could open up a much-needed conversation

Every person reading this article will have some sort of relationship to the concept of depression. Whether that’s through lived experience, witnessing the depression of a friend or loved one, or questioning if the tough time they are currently going through themselves, is in fact depression.

As Psychotherapist John-Paul Davies explains on Happiful’s podcast, while the initial route for diagnosing depression should be through a visit to your GP or a Psychiatrist, depression is a condition he encounters regularly in his practice. He’s eager to share how common it is and to underline the constant possibility for change and a different way of being.

“Depression is very understandable based on our physiology, our environments, the media, and the type of world we live in. It’s a very human response to somebody’s early life, to current circumstances and grief,” John-Paul notes.

“There are most definitely ways we can move through it, albeit it’s a gradual process, but never think that because of what’s happened in the past that you can’t change in the present. There’s always hope and things that we can do to help ourselves.”

So what is depression?

“I would say that as human beings, we’re at our happiest when we’re in the middle band of feelings, which you might describe as ‘calm and alive’,” John-Paul explains. “However, it’s not always possible for human beings to be in that place. If we go above that ‘calm and alive’ band we might be overly aroused, fearful or angry. If we fall below, then we can feel hopeless, helpless, apathetic and in despair. There can be a lack of physical movement that goes with that feeling too. And I think for me, depression is a situation where somebody has a tendency to fall below ‘calm and alive’.”

The impact of depression, he notes, can be far-reaching too. “Depression can have a profound adverse impact, unfortunately on all areas of life for people,” John-Paul shares. “But there can be a range of depressive experiences, some people experience it mildly while, for other people, it’s something that’s been around clinically quite severely for months or even years in their lives.”

What can you do to help yourself?

As well as seeking support from your GP, John-Paul explains that there are multiple ways in which we can start to help ourselves move through a depressive period.

These include:

Connecting with your thoughts

“Become conscious of your thoughts and the types of beliefs that you have about yourself and others. It’s been said that depression is an inability to construct a future, so start to question this. What is it that you would want in the future? Vision boards can help (although I know some people will roll their eyes at this!)

“Paying attention to your thoughts can really help as people with depression will compare themselves less favorably than others. Depression can distort our perceptions of ourselves and others, it can make us feel like we are not doing well, but all human beings struggle.”

Connecting with your feelings

“Often people experiencing depression will have disconnected from their bodies too. Improving the mind-body connection is important. Make your body feel good, try massage, warm showers, cold baths – all the things that can regulate your nervous system and put you in that ‘calm and alive’ place.

“There are lots of other things we can do to regulate the nervous system; handholding, hugs, petting an animal, a walk in nature even for a relatively short period of time can be helpful for lifting depression. Nature has that inherent sense of being calm and alive that does tend to be regulating for people.”

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Photo by Clem Onojeghuo

Embracing creativity

“Using your imagination to make something rather than to imagine the worst outcomes can be really helpful. This doesn’t have to involve going out with large groups of people or spending lots of money. It could be writing, art, or thinking about how you’d decorate a room in your home. Creativity is so important.”

Cultivating relationships

“An important way through depression is via relationships. Cultivate relationships with others, and notice the effect that people have on our minds and bodies. Does it make you feel more alive to be around certain people? Can you lean into that?”

Taking care of media consumption

“Quite a lot of people are spending time looking at the media which is frightening and angering them. The thing that can be reinforcing depression is that they’re not in control of it. That’s where feelings of hopelessness and helplessness can arise. So be careful around the sorts of media you consume.”

How can working with a therapist help?

While there is much we can do to help move through a depressive state, there will be situations where we need the support of a mental health professional, and this, as John-Paul explains, can be transformational.

“It’s important to have your experience seen and heard,” he explains. “Depression can be deeply ingrained. Therapists can combine acceptance therapy with discussions around compassion, commitment and how things might be different but ultimately the power of just listening to what someone’s saying is crucial for future progress.”

 

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