correcting-altered-brain-circuit-could-tackle-coinciding-obesity-and-depression

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Research has found that obesity and mental disorders such as depression and anxiety seem to often go hand in hand. Researchers at Baylor College of Medicine and collaborating institutions are providing new insights into this association by identifying and characterizing a novel neural circuit that mediates the reciprocal control of feeding and psychological states in mouse models.

Similar to human patients, mice that consumed a high-fat diet not only became obese but also anxious and depressed, a condition mediated by a defective brain circuit. When the researchers genetically or pharmacologically corrected specific disruptions they had observed within this circuit, the mice became less anxious and depressed and later lost excess body weight.

Interestingly, weight loss was not the result of lack of appetite, but of the animals’ change of food preference. Before the treatment, the mice naturally preferred to eat a high-fat diet, but after the treatment, they turned their preference toward a healthier diet with reduced fat and abundant protein and carbohydrates. The findings, published in the journal Molecular Psychiatry, for the first time, not only reveal a key regulatory mechanism for coinciding obesity and mental disorders but also suggest the possibility of pharmacological treatment.

“Reports indicate that 43% of adults with depression are obese and that adults with mental illness are more likely to develop obesity than those who are mentally healthy,” said corresponding author Dr. Qi Wu, a Pew Scholar for Biomedical Sciences, Kavli Scholar and assistant professor in pediatrics-nutrition at Baylor’s Children’s Nutrition Research Center. “Factors such as hormonal dysregulation, genetic deficiency, and inflammation have been proposed to be involved in the connection between obesity and mental disorders. Here we provide evidence that supports the involvement of a neural component.” To investigate the neuronal circuits that could be involved in reciprocally regulating weight gain and depression or anxiety, the researchers provided mice with a high-fat diet. As expected, the animals became obese. They also developed anxiety and depression. In these mice, the team studied the function of neuronal circuits.

“We discovered in normal mice that two groups of brain cells, dBNST and AgRP neurons located in separate brain areas, form a circuit or connection to each other by extending cellular projections,” said co-first author Dr. Guobin Xia, a postdoctoral associate in the Wu lab. “This newly discovered circuit was malfunctioning in mice that were both obese and depressed.”

“Using genetic approaches, we identified specific genes and other mediators that were altered and mediated the circuit’s malfunction in the obese and depressed mice,” said co-first author Dr. Yong Han, a postdoctoral associate in the Wu lab.

“Importantly, genetically restoring the neural defects to normal eliminated the high-fat diet-induced anxiety and depression and also reduced body weight,” Xia said. “We were surprised to see that the animals lost weight, not because they lost their appetite, but because genetically-aided readjustment of the mental states changed their feeding preference from high-fat to low-fat food.”

“Keeping in mind translational applications of our findings to the clinic, we investigated the possibility of restoring the novel circuit pharmacologically,” Wu said. “We discovered that the combination of two clinically-approved drugs, zonisamide and granisetron, profoundly reduced anxiety and depression in mice and promoted weight loss by synergistically acting upon two different molecular targets within our newly identified brain circuit. We consider that our results provide convincing support for further studies and future clinical trials testing the value of a cocktail therapy combining zonisamide and granisetron (or a selection of their derivatives) to treat metabolic-psychiatric diseases.”

Story Source:

Materials provided by Baylor College of Medicine. Originally written by Homa Shalchi. Note: Content may be edited for style and length.

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Effective Strategies To Create A Secure Attachment

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Ways to create a secure attachment

In most of our blogs, we have discussed attachment styles and I observed that everyone is trying to determine human behavior which always leads to a question regarding the rise of “nature vs. nurture.”

Meanwhile, studies show that human behavior is a combination of both. When it comes to marriage, relationship, or parenting, nurture plays an important role because it tends to have a healthy and secure attachment that helps to long last a relationship especially in a marriage.

Indeed, an insecure attachment style is negative and leads us to the fear of abandonment. And sadly, it’s quite common these days.

In this article, I am going to tell you effective ways to create a secure attachment that helps you in recalling relationships and strengthening your relationships or bonds with others as well.

So, let’s get started.

Effective Ways to Create Secure Attachment

1. Try to build self-esteem

Try to build self-esteem

Self-forgiveness comes along with the creation of self-esteem. When you will let your thoughts free and will free yourself from the pain of the past, you will be able to work on yourself again. In order to keep your mental health intact, try to practice positive self-talk and try to build self-esteem in these ways:

1. Do not neglect yourself. And try to make yourself a priority by also practicing self-compassion. If you want to keep it better, do not neglect your personal needs and desires. Always remember that you don’t have to be perfect, it’s just you have to polish your personality.

2. In order to build great self-esteem, take a blank book and start writing three compliments for yourself each morning. This habit helps in providing positive attributes and works as an affirmation.

3. Try to find activities that fulfill If you enjoy photography, take out your camera, and click whatever you want. Do whatever makes you happy; just try to spend quality time with your hobbies.

2. Keep your focus on self-healing

Keep your focus on self-healing

Insecure attachments are due to childhood trauma or experiences that created self-esteem and guilt issues in your life. While living with this guilt can result in self-destructive behaviors or self-sabotaging.

In order to heal from the guilt and self-esteem issues, you will need to form a secure attachment with the help of healing strategies. If you are wondering how to self-forgive yourself and move on with a secure attachment style, don’t worry here are some ways that can help you with self-healing:

1. Try to evaluate your past decisions and do not reflect on them if they seem to be wrong.

2. Step into the light of self-forgiveness and be responsible for your actions. If you think you have done something wrong, start apologizing. It will help you in moving forward in life.

3. If you are comfortable, try to take the help of self-compassion exercises that will help you to make it through the healing procedure.

3. Acknowledge your issues

Acknowledge your issues

The most effective way to confront the negative aspects of your insecure attachment style is to start acknowledging it and to start your focus on moving forward.

By acknowledging, you will be able to build self-esteem, you are going to feel more confident and content about yourself and this will help you in forming healthy and secured relationships with others.

Do not remain silent and start acknowledging by speaking up what’s inside you so that you can start feeling better.

In order to acknowledge your needs and issues, you can try:

  • Reading self-compassion books or articles
  • Try to maintain close relationships with others.
  • Read resources related to different attachment styles and you can also watch ted-talks.

4. Seek professional help

Seek professional help

In addition to the above-mentioned strategies, therapy or counseling can help you in accelerating the healing process. Research shows that Emotionally Focused Therapy (EFT) helps us to bring a major difference when we really want to improve our relationships while dealing with insecure attachment issues.

You can easily get this therapy through online platforms. If you are considering online therapy, you can seek help from a counselor from BetterHelp. To connect with a professional counselor from BetterHelp, click here.

I hope this blog helps you with effective ways to create a secure attachment. Comment down and share your thoughts on creating a secure attachment style. For more such content, connect with us on all social media platforms.

Thanks for reading!

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Mental Illness At University — How Students Can Effectively Cope When Returning To Study – FE News

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High levels of anxiety, loneliness, substance abuse, and even thoughts of self-harm were discovered as a result of a poll of almost 38,000 UK students, suggesting that rates of psychological distress and illness are on the rise in universities. When it comes to returning to university after taking a break due to mental health issues, many students struggle with recovery, and could potentially end up in an even worse situation than they were in before taking leave. From the importance of asking for help to maintaining a positive environment, there are several notable ways that students can take action.

Asking for help

For many students, asking for help is imperative in order to stay on the path to recovery and adjust to university life, but they may be hesitant due to the negative stigma associated with doing so. Thankfully, universities are working to help by offering a wide range of helpful resources. The University of Cambridge, for example, has University Counselling services that offer a variety of support, including mental health advisors, workshops, and self-help resources such as guides and books.

Many other universities also have a number of resources available to aid in adjusting back to life on campus after a mental health break. These may include extensions on deadlines, and peer support groups. Some universities may offer student-led options as well. While they aren’t qualified counselors, talking to someone who is a similar age may be more approachable for those who are struggling and could bring valuable insight into readjusting to university life when dealing with issues like stress. 

Managing treatment effectively

Properly managing mental health treatment may be another area of difficulty when students are adjusting back to university life. Mishandling mental health treatments, such as by skipping medication doses or missing doctor/therapy appointments, can be detrimental to recovery. However, while such an issue can be rectified with a proper schedule and utilizing university resources, those who have been on the same antidepressants for years may find themselves with another issue entirely. 

While antidepressants may work well for many people, those who have been taking antidepressants for several years may begin to feel as though the treatment is no longer helping. However, unconventional options may offer a unique solution for those whose treatment has come to a standstill, and recent research shows that the use of psychedelic drugs may hold a number of benefits to those struggling. Treating post-traumatic stress disorder (PTSD) with the drug MDMA, or ecstasy, is just one example of treating mental illness with psychedelics: MDMA helps people to feel more relaxed and be more open with their therapist, and can even help patients to explore their trauma. This can help greatly in processing trauma effectively, although it’s certainly not the right treatment for everyone. University mental health services should ensure that all students are aware of their options so they can make the right decision for them.

Maintaining a positive environment

There’s no doubt that uni life can wreak havoc on someone already experiencing a mental health issue. This is particularly problematic for students with random mealtimes, a lack of routine and sleep, and exam stress. It can also be exacerbated by heavy drinking and party-hard lifestyles. By making it a point to keep a regular schedule, you can effectively make healthier lifestyle choices and stick to a regimen that benefits your mental health. Maintaining a positive environment can also be done by surrounding yourself with a support network, which studies show can improve the ability to cope with stressful situations and alleviate the effects of emotional distress.

It’s common for students to face mental health challenges during their life at university, and taking a break from studies can be helpful in order to help them recharge and seek treatment. For those returning to university life, however, challenges may arise due to university culture, highlighting the importance of seeking help and maintaining a positive environment. Universities can help by ensuring provision is in place to help those most in need.

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Addressing Mental Illness Requires Workplace Policy As Well As Health Care Policy – Health Affairs

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Health policy usually focuses on the delivery of health care. But in many situations, health care alone is not enough to meaningfully improve people’s lives. One of the most common situations in which this is the case is mental illness. Nearly one in five adults, or 51.5 million people, in the United States, meets diagnostic criteria for a mental illness, which can impair functioning across a spectrum of severity, ranging from mild to moderate to severe. Yet, despite advances in the diagnosis and treatment of these conditions, and considerable progress on including mental health care in health insurance, people with mental illness—including those with moderate illnesses such as depression or anxiety—continue to be tenuously connected to work and, hence, to full participation in society. 

Working With Mental Illness

Mental illnesses pose difficulties for workers because their symptoms can interfere with essential workplace skills, such as participating effectively in teams, interacting with customers and co-workers, and maintaining concentration. For people with severe illnesses such as schizophrenia or bipolar disorder—about 2 percent to 3 percent of the population—these symptoms can be disabling. But the negative effects on employment of moderate mental illness, which affects 7.5 percent to 9.0 percent of the US population, are also substantial. In the mid-2010s, for example, 77 percent of those without a mental illness participated in the labor force, but only 55 percent of those with moderate mental illness were working or actively looking for work. People with moderate mental illness who do work may have reduced productivity or interpersonal problems at their jobs, and their symptoms may lead them to miss work. The overall effect of these job challenges is that people with moderate mental illnesses have lower earnings and accumulate less work experience and fewer skills over their lives.

These labor market consequences are particularly troubling because we already have on-hand tools that would allow us to address them much more effectively. Medical treatment alone isn’t enough—but we can significantly mitigate the negative workplace consequences of illness using a combination of clinical, workplace, and policy interventions. These interventions integrate innovative programs that combine clinical care and workplace supports; workplace accommodations, which have been required under the Americans with Disabilities Act (ADA) for 30 years; and comprehensive benefits, including health insurance coverage and paid leave. Together, this framework could go beyond “usual care” and improve both mental health and workplace productivity for this population.

Exhibit 1: A combination of clinical, workplace and policy interventions working together would likely improve work outcomes and labor force participation among Americans with moderate mental illness

Source: Authors’ creation.

Clinical Treatment Combined With Workplace Interventions

Most studies examining workplace interventions have focused on depression, which affects at least 4.7 percent of adults ages 18 and older in the US. Standard, guideline-concordant treatment, including the use of antidepressants and other pharmacotherapies and psychotherapy, can be effective in reducing symptoms and improving life satisfaction and overall health for depressed workers. When treatment leads to a reduction in depressive symptoms, work impairments are reduced and work outcomes improve.  

Treatment alone, however, is often not sufficient to maintain stable labor force engagement. Employees may still face difficulties after symptoms subside, and effective functioning at work can be disrupted by residual symptoms and incomplete recovery, suboptimal treatment administration or adherence, stigma, and difficulty reestablishing good work habits. Specialized interventions focused on work-related outcomes build on these clinical treatments by combining medication therapy, psycho-social treatments such as cognitive-behavioral therapy (CBT), and job coaching.

One example of such an intervention is the Work and Health Initiative (WHI), which integrates vocational and mental health improvement techniques through an Employee Assistance Program (EAP) counselor for depressed workers. Through telephone sessions, the counselor provides medical care coordination and work coaching to reduce personal or environmental barriers to effective functioning at work, developing a customized plan to change specific work behaviors, work processes, or environmental conditions. The intervention also provides work-focused CBT to help participants learn to identify the thoughts, feelings, and behaviors that are eroding their work functioning and to respond with more effective coping strategies. Randomized trials have shown that WHI works; it both reduces depression symptom severity and greatly improves areas of functioning including time management and mental-interpersonal job tasks. In the treatment group of one trial, at-work productivity improved 44 percent (compared to 13 percent in the usual care group), absence days declined by 53 percent (compared to 13 percent in the usual care group), and absence-related productivity loss improved 49 percent (compared to 11 percent in the usual care group).

Similar programs have also shown benefits in Europe, with impressive results in terms of time to full return to work and days of missed work due to incapacity. As always, the size of effects from experimental interventions may be hard to replicate in routine practice, but a review of the broader evidence suggests that interventions that combine elements of these programs with CBT-based treatment are promising.

Workplace Accommodations: The Americans With Disabilities Act

Strategies such as WHI that involve both clinical interventions and workplace supports require active employer involvement. One potential policy lever for promoting such engagement is the ADA, which requires employers to offer workplace accommodations to compensate for the disadvantages faced by people with disabilities (including mental illness-related disabilities). Individuals qualify as having a disability under the ADA if they have a physical or mental impairment that substantially limits a major life activity, such as concentrating, thinking, communicating, seeing, or hearing—all forms of impairment that are consistent with many moderate mental illnesses. Employers are required to provide reasonable accommodations—such as assistance during hiring or on-the-job, flexible scheduling and part-time work, and modified job duties and descriptions—to people with qualifying impairments. Job coaching, switching from full-time to part-time work hours, and gradual introduction of tasks—the kinds of workplace changes incorporated in the targeted interventions described above—are among the most common accommodations. Research suggests that these accommodations can be helpful in keeping people at work and in reducing disability claims.

Although the ADA offers opportunities for workplace accommodation, workers with mental illnesses have been historically much less likely to receive accommodations than employees with physical impairments, and this pattern continues today. This is partly attributable to the ambiguity surrounding what constitutes a reasonable accommodation and which accommodations will best help enable employees with psychiatric impairments fulfill their job tasks. Lower rates of workplace actions to address mental illness may also reflect real or perceived stigma. A recent survey reported by the Society for Human Resource Management indicated that more than two-thirds of employees worry that asking for help with a mental health condition would imperil their jobs, consistent with the low rates of help-seeking observed in the workplace.

Comprehensive Benefits For Workers With Mental Illness

Deployment of effective interventions that combine clinical treatment and employer supports will also require financing. Under the rules established by the Mental Health Parity and Addiction Equity Act, employer-sponsored health insurance coverage should provide access to appropriate psycho-social services, such as CBT. Many large employers already have EAPs that might provide a foundation for additional work supports. But because of the episodic nature of the mental illness, maintaining employment is also likely to require flexibility to take time off work when symptoms are exacerbated.

Under the ADA, an individual with a qualifying disability may work part-time or occasionally take time off as a reasonable accommodation if it would not impose an undue hardship on the employer. The US Department of Labor lists flexible scheduling, sick leave for reasons related to mental health, additional unpaid or administrative leave for treatment or recovery, and leaves of absence or occasional leave for therapy and related appointments as “some of the most effective and frequently used workplace accommodations.”

However, the potential help of flexible scheduling and flexible use of sick leave or other leave is quite limited when employers do not provide paid sick leave. While employees may be entitled to take time off work without losing their jobs, they will lose income. As of 2020, only 78 percent of civilian US workers are eligible for any paid sick leave. Among employed 50-year-old men with depression surveyed between 2008 and 2014, 42 percent had fewer than three days of paid sick leave available (authors’ analysis of the National Longitudinal Surveys of Youth). While several states and localities now mandate that workers have access to paid sick leave, most Americans are not covered by these mandates (although their employers may voluntarily provide paid sick leave). Congress is considering legislation that would expand mandated paid sick leave to all workers across the country (for example, H.R.1185/S. 463, the Family and Medical Insurance Leave Act, or S.840, the Healthy Families Act). Such legislation would provide a key support to efforts to increase and maintain labor force participation and workplace engagement among people with moderate mental illnesses.

We Can Do Better For People With Mental Illness By Thinking Beyond Medical Care

Health policy discussions often focus on coverage for the costs of medical care. As the circumstances of the large population with moderate mental illness suggest, medical coverage is necessary, but not sufficient, to protect people against the workplace consequences of illness. Americans with moderate mental illness typically work, but people with these conditions are at high risk of missing work or losing their jobs because of functional impairments caused by their mental health problems. Specialized interventions, such as work-focused CBT and job coaching, can mitigate some of these effects. Increasing the use of these interventions will require more than expanded insurance coverage. It will also require more aggressive use of the protections offered by the ADA and expansion of access to paid sick leave, so that workers with mental illnesses can afford to modify their schedules to fit their mental health needs and accommodate medical or therapy appointments or time for recovery.

Authors’ Note

Sherry Glied is a director of NRx Pharmaceuticals, Inc., which has a behavioral health drug in development.

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Understanding Depression: Does Depression Ever Go Away?

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Can Depression Go Away On Its Own

Depression is a little more than just feeling “low” or “blue”, it is a serious mental health condition that can have severe long-lasting effects on a person’s health and wellness.

Depression is often accompanied by sadness and while sadness is a common emotion, depression can enhance the feelings of sadness, hopelessness, worthlessness, and other emotions.

While depression can be treated, some questions are left unanswered; how long does depression last, and does depression ever go away? To understand the answers to these questions, we need to understand a little about depressive episodes and risk factors that can contribute to recurring depression.

Understanding Depressive Episodes

Depression is a serious mental health disorder that, if left untreated, can cause a person difficulty in functioning normally in their daily lives. A depressive episode is when a person experiences the symptoms of depression for at least or more than two weeks.

How long do depressive episodes last?

The span of the episode might vary. For instance, someone may experience only one episode while someone with a depressive disorder may have recurring episodes during their lifetime. If left undiagnosed or untreated, the symptoms can worsen over time and may interfere with a person’s job, home-life, relationships, and might also lead to thoughts of suicide or self-harm.

Risk Factors For Recurring Depressive Episodes

Risk factors can depend on contributors such as genetics, environment, exposure to trauma, etc. Examples of risk factors include:

  • The severity or intensity of the first depressive episode
  • Presence of another underlying mental health disorder
  • Family or medical history of depressive disorders
  • Presence of stress in life
  • Recent exposure to trauma
  • The lack of social support and acceptance

Among others. While there is no average span for depression symptoms, to be diagnosed with depressive disorders, a person must experience the symptoms for at least two weeks or more and must meet the criteria defined in the DSM-5.

Can Depression Go Away On Its Own?

While it is true that time heals all wounds, it might not be true in the case of depressive disorders or depression, in general. The answer to the question, can depression go away on its own, can be based on different factors such as:

1. Types

There are different types of depression and their symptoms can also differ in terms of length. For instance, SAD (Seasonal Affective Disorder) occurs during the winter season but seems to ease during summertime. On the other hand, dysthymia symptoms can last longer than two years.

2. Causes

Causes of depression can also affect the duration of the disorder. For instance, if depression is caused by a specific situation then there is a possibility it may not last longer than few weeks. However, if depression is a result of another mental health condition, such as Postpartum Depression, then the duration of the depression may last longer than few weeks.

3. Intensity

The intensity of the depressive episode can also be a factor. For instance, if someone is diagnosed with mild depression, then it may be treated without any formal treatment (psychotherapy or medications) but if someone is diagnosed with moderate or severe depression, then they might require formal treatment.

How Long Can Depression Last?

The good news is that depression can be treated! Psychotherapy is one of the most effective treatment options when it comes to treating depression. Although, a combination of psychotherapy, medications, and self-help can also help treat depression.

Please keep in mind that the treatment might not be the same for all and factors such as individual personality, symptoms, and severity must be taken into account.

1. Psychotherapy

Psychotherapy, also referred to as talk therapy is the first line of defense when it comes to treating depression and related disorders. Therapies such as cognitive-behavioral therapy and dialectical behavioral therapy are more common.

Talk therapy can help in:

  • Identifying the triggers
  • Reframing negative thinking patterns with positive thinking
  • Provide effective coping techniques to help in the future

Psychotherapy treatments are tailored according to the individual’s personalities, experiences, symptoms, goals, etc.

2. Medications

Medications are often combined with psychotherapy and while one type of medication might work for you, it might not work for others. However, medications should always be taken as prescribed by your doctor and over-the-counter medications should be avoided.

Antidepressants can have side effects that may worsen your condition, therefore, it is recommended you take prescribed medications only.

3. Electroconvulsive Therapy (ECT)

While ECT is not a widely used therapy treatment, it can be effective in treating severe depression or catatonic depression. ECT is used when the patient is unresponsive to other therapy treatments. This treatment option can have side effects such as memory loss and must be performed under the supervision of a professional.

4. Lifestyle Changes

To treat or prevent recurring depression, you can try:

  • Following your therapy plan and continue going to therapy sessions
  • Avoid alcohol, recreational drugs, caffeine, or other harmful substances
  • Try to exercise regularly, maintaining a routine, and eating a well-balanced diet
  • Getting enough sleep and staying active
  • Asking for support from your support system

5. Alternative Treatments

Alternative treatment options can include:

Does Depression Ever Go Away?

No one can guarantee that depression can go away, permanently. More often than not the outcome depends on time, type, symptoms, severity, and causes of the depression. While some people may recover from depression completely, others may be more prone to depression relapse.

Since depression can be treated, you can consult a psychologist and create a plan in case you fear a relapse. Remember that some kinds of depression may not be easy to treat and may require years of therapy and treatment.

Getting the right treatment should be the priority. I hope this article answered the question; Does Depression Ever Go Away? For more, you can contact us at info@calmsage.com or follow us on social media.

You are not alone.

Take care!

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